Laboratory of Liver Cancer Institute

2016-11-14

The Liver Research Laboratory was established under the initiation of academician Tang Zhaoyou, a renowned expert in liver cancer research in China. It was one of the first professional institutes to carry out basic clinical research of liver cancer. It is the support organization of the Ministry of Education’s Key Laboratory on “Principles of Cancer Invasion and Metastasis”. The laboratory took the lead in the world to establish a human liver cancer nude mice xenograft model, and successfully cloned the highly metastatic human hepatic carcinoma cell line HMCC97 with independent intellectual property rights. The model earned the laboratory two first prizes of National Science and Technology Progress Award and a good academic reputation in the related field.

    The Liver Research Laboratory is a National Key Discipline of Oncology, Shanghai Municipal Liver Cancer Medical Center, a Fudan University “Top Priorities” Construction Discipline and a key specialty in oncology as a construction discipline in “Project 211”. As a training facility for the graduate and PhD programs in oncology, the laboratory trains near a hundred top talents specializing in basic and clinical research of liver cancer every year. The laboratory has successively undertaken or participated in key research projects from Major State Basic Research Development Program of China (“Program 973”), National Natural Science Foundation of China, National Programs for Science and Technology Development in the Sixth to Twelfth Five-year Plans, National Health and Family Planning Commission Key Discipline Foundation.

The director of the laboratory is Dr. Wu Weizhong, and the associate director is Dr. Liu Binbin. There are 18 permanent staff, with a professor, a research fellow, 5 associate research fellows, a senior laboratory engineer, 5 assistant research fellows, a charge technician and 4 staff technicians. Twelve of the staff members have doctoral degree, 1 has master’s degree, 1 is doctoral supervisor and 6 are master student supervisors. The laboratory has 7 ongoing general projects and 3 ongoing young people’s projects from National Natural Science Foundation of China. We also participate in 3 major projects from “Program 973” and National Infectious Disease Projects, as well as 4 projects from Shanghai Municipal Science and Technology Commission. The laboratory staff publishes 10-15 SCI articles per year with an impact factor around 60-67. The staff has also obtained 8 national invention patents.

The laboratory has set up a high-level cancer metastasis research platform for experimental researches in cancer genomics, proteomics, molecular biology, cell biology and establishment of nude mouse xenograft model. The laboratory is equipped with Cell Sorting Epics Altra Flow Cytometry (Beckman Coulter, USA), In Vivo Fluorescence Imaging System, Laser Capture Microdissection (LCMD), Microscopic Camera, Cell Image Analysis System, Autostainer System, Image Scanner, Ettan Sport Picker, ABI Capillary Electrophoresis Instrument, Biocard Perfusion Chromatography, DNA and Peptide Synthesizer, Backman High-Speed Centrifugation, Microplate Reader, PCR Instruments and VDS Gel Image Analysis System, etc. In addition, the laboratory owns a tumor tissue bank including complete pathological diagnosis and clinical follow-up data of 100,000 liver cancer cases.

The laboratory always adheres to its philosophy of “fostering talents with research projects and improving research with talent cultivation”. We strive to continually improve our scientific research quality. In the meantime, we have done an outstanding job in accomplishing various research and didactic teaching tasks for Fudan University Institute of Liver Cancer, Fudan University Affiliated Zhongshan Hospital as well as for the Ministry of Education’s Key Laboratory on “Principles of Cancer Invasion and Metastasis”.

We welcome liver cancer research collaboration with peers both at home and abroad, and look for young and talented scientists and technicians to join us in liver cancer research.

Contact: Dr. Zhang Shu, E-mail: zhang.shu@zs-hospital.sh.cn